Split Dynamics Enhancing Cancer Detection

Split Dynamic MRI represents a breakthrough in medical imaging, utilizing high temporal and spatial resolution to revolutionize tumor diagnosis. This technique, by merging rapid sequence acquisition with detailed imagery, offers unparalleled precision in distinguishing between malignant and benign lesions. By providing clearer, more detailed images, Split Dynamic MRI aids clinicians in making more accurate diagnoses and treatment plans, particularly in complex cancer cases.

Key benefits include faster diagnosis times, reduced need for repeat scans, and the potential to identify cancers earlier in their development. This not only enhances patient care but also streamlines the diagnostic process in oncology.

We have thoroughly investigated the clinical utility of the Split Dynamic MRI data. Our findings indicate that high temporal resolution combined with dynamic T1 -weighted and R2* assessment provides a high diagnostic accuracy when differentiating malignant from benign breast masses. Our findings also indicate that the additional kinetic information, combined with BI-RADS interpretations from high spatial resolution image series, improves the diagnostic accuracy in the assessments of breast masses compared to BI-RADS interpretations alone.

Description for New Image

The MR pulse sequences utilized during the dynamic development of MR signals include the commonly employed T1-weighted THRIVE sequence, which is globally recognized for producing high spatial resolution images when a contrast agent is administered. By employing a multi-echo EPI pulse sequence, it becomes possible to visualize both the dynamic T1 signal (M0) and the dynamic R2* (R2*=1/T2*). During the scanning process, both the THRIVE and EPI sequences are applied in an alternating manner, resulting in two sets of dynamic MR data: one with high spatial information (THRIVE) and one with high temporal information (EPI).


Observed tumor heterogeneity

Observed rectal tumor heterogeneity. E. Grøvik et al, JMRI 2017.

The dynamic R2* signal in tumor

The dynamic R2* signal in rectal tumor. E. Grøvik et al, JMRI 2017.

Description for Image 3

NordicCADs method predicts the evolution of rectal cancer for the next five years given standard treatment by measuring the blood flow (BF) in the cancer. K. Bakke et al, Radiology 2020.

Description for Image 4

Signal Intensity curves (M0 and R2*) for different breast lesions. See Grøvik el al JMRI 2013 for details.


Research Articles


Evaluating the "Split Dynamic" Method for Enhanced MR Imaging

Split dynamic MRI: Single bolus high spatial–temporal resolution and multi contrast evaluation of breast lesions

This study introduces the "split dynamic" method in MR imaging, combining high temporal and spatial resolution. It tested the accuracy and reliability of this method through simulations and patient data, focusing on kinetic parameter estimations. Results show effective evaluation of T1- and T2*-weighted characteristics, maintaining parameter reliability and adhering to spatial resolution standards.

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Enhancing Breast Mass Assessment with Split Dynamic MRI

Single bolus split dynamic MRI in Breast Mass Differential Diagnosis

This research focuses on applying the split dynamic MRI technique for assessing breast masses, combining high spatial resolution with dual-echo high temporal resolution data. The study involved 44 women, analyzing both BI-RADS interpretations and quantitative kinetic analysis. Findings indicate significant improvement in diagnostic accuracy for malignancy identification, highlighting the potential of split dynamic MRI as a more effective diagnostic tool in breast imaging.

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Dynamic Multi-Echo DCE- and DSC-MRI in Rectal Cancer

Low Primary Tumor Ktrans and ΔR2* Peak Are Significantly Associated with Lymph Node Metastasis

This pilot study implements a dynamic contrast-based multi-echo MRI sequence in assessing rectal cancer, correlating histopathologic data with DCE- and DSC-MRI parameters. Data from 17 patients with resectable rectal cancer were analyzed. The study found significant associations between lower Ktrans and ΔR2* peak in the primary tumor and lymph node metastasis, demonstrating the feasibility and potential of this method in patient stratification for intensified multimodal treatment.

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MRI Associated with Treatment Response in Rectal Cancer

Sex Differences and Tumor Blood Flow from Dynamic Susceptibility Contrast MRI Associated with Treatment Response in Rectal Cancer

This research with 94 rectal cancer patients found that sex differences and tumor blood flow, measured using dynamic susceptibility contrast MRI, are key predictors of treatment response and survival. Lower blood flow was linked to worse treatment outcomes and shorter survival. Women typically had higher blood flow, impacting prognosis and treatment efficacy.

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